Process and intermediates for the synthesis of obeticholic acid and derivatives thereof
US11104702B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Jun 22, 2018 |
| Grant date | Aug 31, 2021 |
| Priority date | — |
| Expiry date | Jun 22, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07J71/001
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of obeticholic acid and derivatives thereof by:(a) hydrogenation of the double bond and reductive opening of the epoxide of a compound of formula (II) or a salt or solvate thereof (b) conversion of a compound of formula (IIIa) and/or a compound of formula (IIIb), or a salt or solvate thereof, into a compound of formula (I), or a salt or solvate thereof
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