Binding compound and uses thereof
US11104703B2 · kind B2 · utility
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8Claims
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Key dates
| Filing date | Oct 24, 2017 |
| Grant date | Aug 31, 2021 |
| Priority date | — |
| Expiry date | Oct 24, 2037 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/382
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Described are compounds for targeting proteases, e.g. serine proteases and their use in the diagnostic methods and methods for treatment of respiratory diseases such as cystic fibrosis. The compounds have the structure [H]—[B]-[A]; wherein [H] is a hydrophilic group, [B] is a subsite recognition group and [A] is a binding group; wherein A has the formula: —C(0)—CH2—NR1—COOR2 and wherein [B] has the structure: (i) —[CO—CH2—NR3]m-, or (ii) -[AA1-AA2]- or (iii) -(AA1-C0-CH2NR3)— or (iv) —(CO—CH2—NR3-AA1)- or (v) —(C0—CH2—NR4-AA1-AA3)-.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.