Plasma derived cell-free mitochondrial deoxyribonucleic acid
US11104954B2 · kind B2 · utility
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Key dates
| Filing date | Mar 31, 2017 |
| Grant date | Aug 31, 2021 |
| Priority date | — |
| Expiry date | Dec 2, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/68
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present disclosure relates to a method for isolating and amplifying a subject's mitochondrial deoxyribonucleic acid (mtDNA). The method comprises the steps of: isolating cell free deoxyribonucleic acid (cf-DNA) from a plasma sample obtained from the subject; and amplifying the mtDNA within the isolated cfDNA using a polymerase chain reaction with a first primer pair and a second primer pair. The first primer is selected from SEQ ID NO: 1 and SEQ ID NO: 2 and the second primer pair is selected from SEQ ID NO: 3 and SEQ ID NO: 4.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.