System and method for microscopic image processing and determining myelination status using processed images
US11107216B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jan 10, 2020 |
| Grant date | Aug 31, 2021 |
| Priority date | — |
| Expiry date | May 28, 2040 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30024
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
A system and method for microscopic image processing. The method includes cleaning leaks shown in images to create cleaned images, each of the images having a neuron signal intensity, wherein the images include at least one neuron channel image and at least one oligodendrocyte channel image, wherein cleaning the images further includes applying a filtering function to each of the images and adjusting the neuron signal intensity of each of the images based on an output of the filtering function; detecting oligodendrocytes in the cleaned images, wherein each detected oligodendrocyte is a region of the images including an object for which the neuron signal intensity is within a range of neuron signal intensities; and identifying high-intensity sub-regions within each detected oligodendrocyte, wherein each high-intensity sub-region includes at least one high-intensity object, wherein each high-intensity object is an object for which the neuron signal intensity is above a threshold.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.