Metal-enzyme sandwich layers

US11109784B2 · kind B2 · utility

Assignee

• CALIFORNIA INSTITUTE OF TECHNOLOGY · US

Inventors

• Dvin Adalian · Pasadena, US
• Samson CHEN · Pasadena, US
• Muhammad Musab Jilani · Pasadena, US
• Axel Scherer · Laguna Beach, US
• Xiomara L. Madero · Glendale, US
• Richard D. Smith · Opelika, US

Key dates

• Filing date: Nov 14, 2018
• Grant date: Sep 7, 2021
• Expiry date: Oct 1, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61B5/1473
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Measurement of target analytes is carried out with an enzyme-based sensor. The enzyme hydrogel is protected by a porous layer of a metallic material. The size of the pores is small enough to prevent degradation of the enzyme layer caused by the immune system of an organism, but large enough to allow transfer of molecules that participate in the electrochemical reaction allowing the enzyme to detect the target analytes.