Method of measuring efficacy of treatment for an autoimmune disease in vivarium animals
US11109801B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Sep 21, 2019 |
| Grant date | Sep 7, 2021 |
| Priority date | — |
| Expiry date | May 16, 2040 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61D99/00
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method of measuring efficacy of test treatment of an autoimmune disease in an animal in a vivarium is described. Animal activity data is collected at multiple times during the night. Sequential time regions of the night are identified as high-activity, activity-drop, or low-activity regions. Embodiments are described to quantify a drop, during the night, of an animal's activity level. These quantified activity-drop scalars for consecutive nights are accumulated in an animal health dataset. This dataset is compared to healthy animals, a standard of care or a reference treatment for the first disease to determine efficacy of the test treatment. One embodiment quantifies an activity-drop by fitting straight-line curves through the data in the three nightly regions. Other embodiment uses a Fourier transform on a circle, LASSO, RANSAC or regression analyses for curve fitting. Another embodiment compares areas under data curves in the regions. Animals may be housed in cages with other animals.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.