Microspherical sustained-release injection containing escitalopram and method for preparing same
US11110061B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 1, 2018 |
| Grant date | Sep 7, 2021 |
| Priority date | — |
| Expiry date | Nov 1, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/501
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a biodegradable polymer microsphere-containing sustained-release injection containing escitalopram as an active ingredient, and to a method for manufacturing the same. In the case of escitalopram microspheres, there is a problem of low encapsulation rate, fracture due to weak strength, and initial over-release due to the phase separation of the liquid drug and the polymer inside the microspheres. In order to solve the problem, it is possible to maximize the encapsulation amount and the encapsulation efficiency of the escitalopram adding a hydrophobic solidifying agent to uniformize the non-uniform phase, to overcome the cracking of the microspheres at high loading conditions, and to properly control the initial release and release delay of the microspheres.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.