Coumarin derivatives, processes for their preparation and uses thereof for the treatment of cancer

US11111238B2 · kind B2 · utility

Assignees

• Lead Discovery Center GmbH · DE
• Max Planck Gesellschaft zur Förderung der Wissenschften e.V. · US
• SOTIO a.s. · CZ

Inventors

• Raffaella Di Lucrezia · Wuppertal, DE
• Tim Bergbrede · Dortmund, DE
• Peter Nussbaumer · Schwanenstadt, AT
• Uwe Koch · Roma, IT
• Bert Klebl · Dortmund, DE
• Axel Choidas · Herdecke, DE
• Anke Unger · Dortmund, DE
• Nils-Göran Larsson · Huddinge, SE
• Maria Falkenberg-Gustafsson · Mölndal, SE
• Claes Gustafsson · Belmont, US

Key dates

• Filing date: Sep 20, 2018
• Grant date: Sep 7, 2021
• Expiry date: Sep 20, 2038

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides novel coumarin derivatives as specific mitochondrial RNA polymerase inhibitors for the treatment of cancer.