Conditionally active chimeric antigen receptors for modified t-cells
US11111288B2 · kind B2 · utility
4Cited by
53References
23Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Sep 7, 2018 |
| Grant date | Sep 7, 2021 |
| Priority date | — |
| Expiry date | Jul 12, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This disclosure relates to a chimeric antigen receptor for binding with a tumor specific target antigen. The chimeric antigen receptor comprises at least one antigen specific targeting region evolved from a parent protein or a fragment thereof and having a decrease in activity in the assay at the normal physiological condition compared to the activity in the assay under the aberrant condition. A method for producing the chimeric antigen receptor is also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.