Delivery of biomolecules to immune cells

US11111472B2 · kind B2 · utility

Assignees

• Massachusetts Institute of Technology · US
• President and Fellows of Harvard College · US

Inventors

• Armon R. Sharei · Watertown, US
• Shirley Mao · Cambridge, US
• George Hartoularos · Boston, US
• Sophia Liu · Boston, US
• Megan Heimann · Baltimore, US
• Pamela Basto · New York, US
• Gregory Szeto · Cambridge, US
• Siddharth Jhunjhunwala · Bengaluru, IN
• Darrell J. Irvine · Arlington, US
• Robert S. Langer · Newton, US
• Klavs F. Jensen · Lincoln, US
• Ulrich H. von Andrian · Sharon, US

Key dates

• Filing date: Oct 30, 2015
• Grant date: Sep 7, 2021
• Expiry date: Oct 30, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2527/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method and device for preferentially delivering a compound such as an antigen to the cytosol of an immune cell. The method comprises passing a cell suspension comprising the target immune cell through a microfluidic device and contacting the suspension with the compound(s) or payload to be delivered.