Compositions and methods for enriching populations of nucleic acids

US11111520B2 · kind B2 · utility

Assignee

• KARIUS, INC. · US

Inventors

• Timothy A. Blauwkamp · Palo Alto, US
• Fred Christians · Los Altos Hills, US
• Igor D. Vilfan · East Palo Alto, US
• Scott A. Smith · Waterford, CA
• Michael Kertesz · Menlo Park, US

Key dates

• Filing date: May 17, 2016
• Grant date: Sep 7, 2021
• Expiry date: Mar 7, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/6809
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

This disclosure provides methods and compositions that are useful for enriching a particular population of nucleic acids (a “population of interest”) within a complex mixture of nucleic acids. The population of interest may make up a minor portion of a complex mixture of nucleic acids. The methods and compositions provided herein are useful for detecting, predicting, diagnosing, or monitoring a disease or disorder, particularly a disease or disorder caused by a foreign microbe or pathogen.