Echinomycin formulation, method of making and method of use thereof
US11116726B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Nov 9, 2016 |
| Grant date | Sep 14, 2021 |
| Priority date | — |
| Expiry date | Nov 9, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K9/1277
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A liposomal drug formulation for treating a disease in a patient characterized by overexpression of HIF-1α and/or HIF-2α includes a plurality of liposomes in a pharmaceutically acceptable carrier. The liposomes encapsulate echinomycin and are made from a peglyated phospholipid, a neutral phosphoglyceride, and a sterol. The PEGylated liposomes may be used to treat proliferative diseases, leukemia, cancer, autoimmune diseases and graft-versus-host disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.