Drug delivery systems containing oxidized cholesterols
US11116729B2 · kind B2 · utility
7Cited by
3References
19Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 15, 2020 |
| Grant date | Sep 14, 2021 |
| Priority date | — |
| Expiry date | Jan 15, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/113
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Lipid nanoparticles and compositions thereof are disclosed herein. An exemplary nanoparticle composition includes an ionizable lipid, a phospholipid, a PEG-lipid, and a cholesterol modified with a hydroxyl group near the D-sterol ring. The disclosed nanoparticle compositions can target liver Kupffer cells and endothelial cells more preferentially than hepatocytes which should be beneficial in treating liver diseases in which dysfunctional Kupffer cells and endothelial cells are involved in disease pathogenesis.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.