Chimeric norovirus P particle and preparation and use thereof
US11116831B2 · kind B2 · utility
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Key dates
| Filing date | Jun 29, 2016 |
| Grant date | Sep 14, 2021 |
| Priority date | — |
| Expiry date | Jan 21, 2037 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/55561
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided is a recombinant P particle formed from a norovirus capsid P protein of a chimeric Aβ1-m peptide (m being an integer ranging from 6 to 15), wherein the recombinant P particles form an ordered and repetitive antigen array. Also provided are a nucleotide sequence encoding the recombinant P particle, a pharmaceutical composition comprising same and a use thereof for preparing a medicament for treating or preventing Alzheimer's disease. Also provided is a method for preparing the recombinant P particle.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.