Methylene carbamate linkers for use with targeted-drug conjugates
US11116847B2 · kind B2 · utility
1Cited by
15References
53Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 19, 2014 |
| Grant date | Sep 14, 2021 |
| Priority date | — |
| Expiry date | Dec 19, 2034 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P37/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides Ligand-Drug Conjugates and Drug-Linker Compounds comprising a methylene carbamate unit. The invention provides inter alia, Ligand-Drug Conjugates, wherein the Ligand-Drug Conjugate is comprised of a Self-immolative Assembly Unit having a methylene carbamate unit for conjugation of a drug to a targeting ligand, methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates of the present invention are stable in circulation, yet capable of inflicting cell death once free drug is released from a Conjugate in the vicinity or within tumor cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.