Insertable variable fragments of antibodies and modified α1-α2 domains of NKG2D ligands
US11117969B2 · kind B2 · utility
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9Claims
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Key dates
| Filing date | Jun 24, 2016 |
| Grant date | Sep 14, 2021 |
| Priority date | — |
| Expiry date | Nov 26, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/74
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This application relates generally to the production of polypeptides having specific antigen-binding properties of Fv domains, for example, insertable variable fragments of antibodies, and modified α1-α2 domains of NKG2D ligands. This application further relates to modified α1-α2 domains of NKG2D ligands attached to polypeptides, in some embodiments antibodies or fragments of antibodies. This application further relates to antigen-binding peptides derived from light and heavy chain antibody variable domains, which contain two linker regions and a split variable domain.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.