Graphene-biomolecule bioelectronic devices

US11119097B2 · kind B2 · utility

Assignee

• The Trustees of the University of Pennsylvania · US

Inventors

• Alan T. Johnson · Rancho Santa Margarita, US
• Ye Lu · San Diego, US
• Joseph J. Mitala · Rockville, US
• Bohdana Discher · Philadelphia, US
• Brett R. Goldsmith · Philadelphia, US

Key dates

• Filing date: Nov 20, 2012
• Grant date: Sep 14, 2021
• Expiry date: Nov 20, 2032

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/582
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Provided are devices and methods featuring a nanoelectronic interface between graphene devices (for example, field effect transistors or FETs) and biomolecules such as proteins, which in turn provides a pathway for production of bioelectronic devices that combine functionalities of the biomolecular and inorganic components. In one exemplary application, one may functionalize graphene FETs with fluorescent proteins to yield hybrids that respond to light at wavelengths defined by the optical absorption spectrum of the protein. The devices may also include graphene in electronic communication with a biomolecule that preferentially binds to a particular analyte.