Nanoparticles having poly(ester amide) polymer cores as drug delivery vehicles

US11123304B2 · kind B2 · utility

Assignee

• The Brigham and Women's Hospital, Inc. · US

Inventors

• Omid C. Farokhzad · Sharon, US
• Jun Wu · Houston, US
• Xi Zhu · 红钢城街道, CN
• Jinjun Shi · San Jose, US

Key dates

• Filing date: Feb 3, 2017
• Grant date: Sep 21, 2021
• Expiry date: Feb 3, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/55572
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure relates to nanoparticles comprising a core comprising a poly(ester amide) polymer comprising a repeating unit of Formula (Ia):and a repeating unit of Formula (Ib):wherein W1, W2, X1, A1, X2, A2, and X3 are as described herein, a payload molecule within the core, and a surface layer comprising a targeting ligand that binds or reacts selectively with a receptor on the outside surface of a cell. Methods of making such nanoparticles, and methods of using such nanoparticles as drug delivery vehicles, are also provided.