Methods of treating mental disorders

US11123311B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Bruce D. Hammock · Davis, US
• Christophe Morisseau · West Sacramento, US
• Jun Yang · Shanghai, CN
• Kenji Hashimoto · Kodaira, JP

Key dates

• Filing date: Dec 15, 2016
• Grant date: Sep 21, 2021
• Expiry date: Dec 15, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K45/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides methods for preventing, mitigating, ameliorating and/or controlling psychiatric disorders, including depression, major depression, bipolar disorder, schizophrenia and substance abuse (including addiction and dependence) by administration of an agent that increases epoxy-fatty acids (e.g., an inhibitor of soluble epoxide hydrolase), as sole active agent or in combination with another agent (e.g., an antidepressant, an antipsychotic, an anxiolytic). When co-administered in combination with another agent, one or both agent may be administered at a subtherapeutic dose.