Broken or folded helical peptide or peptide analog exhibiting antimicrobial activity against gram-negative bacteria, and use thereof
US11123400B2 · kind B2 · utility
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Key dates
| Filing date | Sep 19, 2016 |
| Grant date | Sep 21, 2021 |
| Priority date | — |
| Expiry date | Sep 19, 2036 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K47/6455
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific activity of the peptide against the Gram-negative bacterial membrane, or an antimicrobial composition for co-administration, or a conjugate comprising a drug linked to the peptide or peptide analogue, or an antibiotic comprising the same.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.