Alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof

US11123452B2 · kind B2 · utility

Assignee

• INSTITUTE OF MEDICAL SUPPORT TECHNOLOGY, ACADEMY OF SYSTEM ENGINEERING, ACADEMY OF MILITARY SCIENCE · CN

Inventors

• Jing Guan · Shanghai, CN
• Jian Yang · State College, US
• Ying Zhang · Beijing, CN
• Feng Tian · San Diego, US
• Jimin Wu · Nanhu, CN
• Sheng Ding · Changzhou City, CN
• Zhihong Li · San Jose, US
• Chunlai Wang · Beijing, CN

Key dates

• Filing date: Oct 24, 2019
• Grant date: Sep 21, 2021
• Expiry date: Jan 20, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2400/04
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The present invention relates to an alkyl chitosan-graphene oxide composite sponge and preparation method and application thereof. The alkyl chitosan-graphene oxide composite sponge provided by the present invention includes alkyl chitosan and graphene oxide absorbed on the alkyl chitosan, and the adsorbing capacity of the graphene oxide is 3-28 wt. %. In the present invention, alkyl chitosan is used as a matrix to combine graphene oxide and alkyl chitosan; the obtained composite sponge has excellent hemostatic performance and blood absorption capacity. Results of embodiments indicate that the in-vitro whole blood coagulation time is less than 58 s, the hemostasis time of a rabbit femoral artery hemorrhage model is less than 155 s, the hemorrhage mass is less than 5.4 g, and the hemostatic effect is superior to a pure alkyl chitosan sponge or graphene oxide powder when the composite sponge provided by the present invention is used for hemostasis.