Method for modifying microcystins and nodularins

US11124818B2 · kind B2 · utility

Assignee

• Cyano Biotech GmbH · DE

Inventors

• Heike Enke · Berlin, DE
• Wolfram Lorenzen · Berlin, DE
• Stefan Jahns · Berlin, DE
• Dan Enke · Berlin, DE
• Timo Niedermeyer · Halle (Saale), DE
• Julia Moschny · Sulzbach-Rosenberg, DE

Key dates

• Filing date: May 9, 2018
• Grant date: Sep 21, 2021
• Expiry date: May 9, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2500/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method is used for producing a modified non-ribosomal peptide, e.g. a modified microcystin and/or modified nodularin (together CA), including the steps of: a) growing a modified non-ribosomal peptide producing cyanobacteria strain in a culture media, h) adding one or more modified substrates, preferably modified amino acids to said culture, and c) inoculating the non-ribosomal peptide, producing strain the presence of said modified substrates. The thus modified non-ribosomal peptide may be used for the therapy of various diseases.