Serum miRNA marker for OPLL diagnosis and application thereof

US11124832B2 · kind B2 · utility

Assignee

• THE SECOND MILITARY MEDICAL UNIVERSITY · CN

Inventors

• Yang Liu · Columbus, US
• Chen Xu · New Providence, US
• Hao Zhang · Montgomery, US
• Wen Ching Yuan · Shanghai, CN
• Peng Cao · Longbeilingcun, CN
• Huiqiao Wu · Shanghai, CN
• Yuanyuan Chen · Wenzhou, CN
• Xiaolong Shen · Suizhou City, CN

Key dates

• Filing date: Dec 7, 2016
• Grant date: Sep 21, 2021
• Expiry date: Jan 30, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/178
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A serum microRNA (miRNA) marker suitable for early screening and diagnosis of ossification of posterior longitudinal ligament (OPLL) and its application in the diagnostic reagent or kit for the OPLL. Biomarker miRNA-563, miRNA-196b, miRNA-10a and miRNA-129 have high diagnostic value for OPLL, and the development and application of the related serum miRNA biomarker detection reagent kit. It can be applied in the screening of ossification of posterior longitudinal ligament disease, supporting the diagnosis of OPLL more quickly and accurately, evaluate the patient's ossification condition, and may lay down the foundation for improving clinical therapeutic effect.