Patent · US Active

Substituted pyrido[3,4-b]indoles for the treatment of cartilage disorders

US11130755B2 · kind B2 · utility

2Cited by

2References

12Claims

0Family size

Assignee

Sanofi · FR

Inventors

Dirk Gretzke · Frankfurt am Main, DE
Olaf Ritzeler · Bad Soden, DE
Uwe Heinelt · Wiesbaden, DE
Volkmar Wehner · Bischofsheim a.d.Rhön, DE
Friedemann Schmidt · Frankfurt am Main, DE

Key dates

Filing date	Nov 2, 2017
Grant date	Sep 28, 2021
Priority date	—
Expiry date	Nov 2, 2037

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D519/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention relates to 8-aryl-substituted and 8-heteroaryl-substituted 9H-pyrido[3,4-b]indoles of the formula (I), in which A, E, G, R1 to R6 and R10 are as defined in the claims, which stimulate chondrogenesis and cartilage matrix synthesis and can be used in the treatment of cartilage disorders and conditions in which a regeneration of damaged cartilage is desired, for example joint diseases such as osteoarthritis. The invention furthermore relates to processes for the synthesis of the compounds of the formula (I), their use as pharmaceuticals, and pharmaceutical compositions comprising them.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.