2-oxoquinazoline derivatives as methionine adenosyltransferase 2A inhibitors
US11130759B1 · kind B1 · utility
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26Claims
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Key dates
| Filing date | Feb 12, 2021 |
| Grant date | Sep 28, 2021 |
| Priority date | — |
| Expiry date | Feb 26, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/05
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Disclosed herein are certain 2-oxoquinazoline derivatives of Formula (IA): that are methionine adenosyltransferase 2A (MAT2A) inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treating diseases treatable by inhibition of MAT2A such as cancer, including cancers characterized by reduced or absence of methylthioadenosine phosphorylase (MTAP) activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.