CYP-eicosanoid derivatives

US11130772B2 · kind B2 · utility

Assignees

• MAX-DELBRÜCK-CENTRUM FÜR MOLEKULARE MEDIZIN IN DER · DE
• The Board of Regents of the University of Texas System · US

Inventors

• Wolf-Hagen Schunck · Berlin, DE
• Dominik N. Mueller · Berlin, DE
• Robert Fischer · Berlin, DE
• Gerd Wallukat · Berlin, DE
• Anne Konkel · Berlin, DE
• John R. Falck · University Park, US

Key dates

• Filing date: Jan 21, 2015
• Grant date: Sep 28, 2021
• Expiry date: Jan 21, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07F9/4015
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to compounds according to general formula (I) which are analogues of epoxymetabolites produced by cytochrome P450 (CYP) enzymes from omega-3 (n-3) polyunsaturated fatty acids (PUFAs). The present invention further relates to compositions containing one or more of these compounds and to the use of these compounds or compositions for the treatment or prevention of conditions and diseases associated with inflammation, proliferation, hypertension, coagulation, immune function, pathologic angiogenesis, heart failure and cardiac arrhythmias.