Reducing the toxicity of agrobacterium endotoxin
US11130956B2 · kind B2 · utility
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12Claims
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Key dates
| Filing date | May 31, 2018 |
| Grant date | Sep 28, 2021 |
| Priority date | — |
| Expiry date | May 31, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/00023
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to the fields of genetically modified Agrobacterium strains, vaccine adjuvants, and generally molecular biology and immunology. Provided herein are modified Agrobacterium strains that produce lipopolysaccharide (LPS) having reduced toxicity or detoxified lipopolysaccharide, and methods of obtaining such strains for plant-based production of biologies. Also provided herein are uses of reduced or detoxified LPS as adjuvants suitable for clinical use.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.