Pyrrolobenzodiazepines and conjugates thereof

US11135303B2 · kind B2 · utility

Assignee

• MedImmune Limited · US

Inventors

• John A. Flygare · Burlingame, US
• Janet Gunzner-Toste · South San Francisco, US
• Thomas Pillow · South San Francisco, US
• Philip Wilson Howard · London, GB
• Luke Masterson · Cambridge, GB

Key dates

• Filing date: Oct 12, 2012
• Grant date: Oct 5, 2021
• Expiry date: Mar 16, 2035

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A conjugate of formula (A): where Y is selected from a single bond, and a group of formulae A1 or A2: where N shows where the group binds to the N10 of the PBD moiety;