Peptide-containing linkers for antibody-drug conjugates

US11135307B2 · kind B2 · utility

Assignee

• Mersana Therapeutics, Inc. · US

Inventors

• Aleksandr V. Yurkovetskiy · Littleton, US
• Natalya D. Bodyak · Boston, US
• Bingfan Du · Cambridge, US
• Dmitry R. Gumerov · Waltham, US
• Mariya KOZYTSKA · Brookline, US
• Timothy B. Lowinger · Carlisle, US
• Cheri A. Stevenson · Haverhill, US
• Mao Yin · Needham, US

Key dates

• Filing date: Nov 21, 2017
• Grant date: Oct 5, 2021
• Expiry date: Nov 21, 2037

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/6817
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates generally to antibody-drug conjugates comprising peptide-containing linkers and to methods of using these conjugates as therapeutics and/or diagnostics. Also disclosed herein are peptide-containing scaffolds useful to conjugate with a targeting moiety (e.g., an antibody), a drug, or both to produce the antibody-drug conjugates.