Half-curcuminoids as amyloid-beta PET imaging agents
US11135318B2 · kind B2 · utility
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Key dates
| Filing date | Jun 29, 2017 |
| Grant date | Oct 5, 2021 |
| Priority date | — |
| Expiry date | Jun 29, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F5/022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are curcumin analogues that are able to interact with amyloid beta (Aβ) and to attenuate the copper-induced crosslinking of Aβ. Also provided herein are methods of using the compounds as imaging agents of amyloid beta and for the treatment of diseases associated with amyloid beta. Methods of preparing unlabeled and radiolabeled compounds useful for interacting with amyloid beta and pharmaceutical compositions are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.