Histotripsy therapy systems and methods for the treatment of brain tissue

US11135454B2 · kind B2 · utility

Assignee

• THE REGENTS OF THE UNIVERSITY OF MICHIGAN · US

Inventors

• Zhen Xu · Ann Arbor, US
• Jonathan SUKOVICH · Ann Arbor, US
• Aditya S. PANDEY · Ann Arbor, US
• Charles A. Cain · Ann Arbor, US
• Hitinder Gurm · Ann Arbor, US

Key dates

• Filing date: Jun 23, 2016
• Grant date: Oct 5, 2021
• Expiry date: Dec 24, 2036

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N2007/0095
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A histotripsy therapy system configured for the treatment of brain tissue is provided, which may include any number of features. In one embodiment, the system includes an ultrasound therapy transducer, a drainage catheter, and a plurality of piezoelectric sensors disposed in the drainage catheter. The ultrasound therapy is configured to transmit ultrasound pulses into the brain to generate cavitation that liquefies a target tissue in the brain. The drainage catheter is configured to detect the ultrasound pulses. An aberration correction algorithm can be executed by the system based on the ultrasound pulses measured by the drainage catheter to automatically correct for an aberration effect caused by the ultrasound pulses passing through a skullcap of the patient.