Antifungal compounds and uses thereof

US11136291B2 · kind B2 · utility

Assignees

• DANA-FARBER CANCER INSTITUTE, INC. · US
• CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS (C.H.U.V.) · CH
• The General Hospital Corporation · US
• President and Fellows of Harvard College · US

Inventors

• Sara Jean Buhrlage · Somerville, US
• Anders M. Naar · Arlington, US
• Gerhard Wagner · Brookline, US
• Haribabu Arthanari · Brookline, US
• Joy Luz Nishikawa · Cambridge, US
• Andras Pal Boeszoermenyi · Boston, US
• Dominique Sanglard · Épalinges, CH

Key dates

• Filing date: Feb 17, 2017
• Grant date: Oct 5, 2021
• Expiry date: Apr 6, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided herein are compounds (e.g., compounds of Formulae (I), (II), and (III)) which are anti-fungal agents and can be used in the treatment of diseases, including infectious diseases. The invention provides methods of treating diseases in a subject (e.g., infectious diseases such as fungal infections), and methods of killing or inhibiting the growth of fungi in or on a subject or biological sample. The compounds may be used in subjects, in clinical settings, or in agricultural settings.