Processes for the preparation of aryl hydrocarbon receptor ligands
US11136318B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Jun 19, 2020 |
| Grant date | Oct 5, 2021 |
| Priority date | — |
| Expiry date | Jun 19, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/06
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure relates to the preparation of methyl 2-(1H-indole-3-carbonyl)thiazole-4-carboxylate (ITE) and related compounds with high yield, purity, and scalability. The processes apply the use of a Weinreb amide intermediate as a scaffold for the preparation of ITE and structural analogs.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.