Substituted imidazoles as apoptosis signal regulating kinase 1 inhibitors
US11136324B2 · kind B2 · utility
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18Claims
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Key dates
| Filing date | Mar 2, 2018 |
| Grant date | Oct 5, 2021 |
| Priority date | — |
| Expiry date | Mar 18, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D498/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An amide derivative inhibitor and a preparation method and an application thereof. Specifically relating to the compound shown in general formula (I), a preparation method for same, a pharmaceutical composition comprising said compound, and an application of same as an ASK inhibitor for the treatment of neurodegenerative disease, cardiovascular disease, inflammation, autoimmune and metabolic disease, each of the substituents in the general formula (I) being as defined in the description.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.