Methods of O-demethylation
US11136331B2 · kind B2 · utility
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3References
19Claims
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Key dates
| Filing date | Oct 12, 2018 |
| Grant date | Oct 5, 2021 |
| Priority date | — |
| Expiry date | Oct 13, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/485
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
There is provided a novel process for the preparation of a compound of formula I, wherein R1, R2, W, Z and are as described in the description, by demethylation of a corresponding O-methyl derivative with a borohydride-based reagent. This process may be used in the preparation of buprenorphine.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.