Crystalline forms of a fatty acid bile acid conjugate, preparation method thereof and use thereof

US11136347B2 · kind B2 · utility

Assignee

• CRYSTAL PHARMACEUTICAL (SUZHOU) CO., LTD. · CN

Inventors

• Minhua Chen · 安丰镇, CN
• Yanfeng Zhang · Suzhou, CN
• Chunxiang Huang · Suzhou, CN
• Xiaoyu Zhang · Suzhou, CN

Key dates

• Filing date: May 21, 2018
• Grant date: Oct 5, 2021
• Expiry date: May 21, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure relates to novel crystalline forms of compound (I) and processes for preparation and use thereof. Crystalline forms CS3, CS2, CS5 and CS8 of compound (I) of the present disclosure have advantages in at least one aspect of solubility, stability, melting point, hygroscopicity, particle size, bioavailability, processability, purification effect, flowability, adhesiveness, stability in drug product, in vitro and in vivo dissolution, etc., which provides new and better choices for preparation of drug product containing compound (I) and has significant values for future drug development.