Patent · US Active

Decarboxylative conjugate additions and applications thereof

US11136349B2 · kind B2 · utility

3Cited by

0References

19Claims

0Family size

Assignee

THE TRUSTEES OF PRINCETON UNIVERSITY · US

Inventors

David MacMillan · Berkeley, US
Daniel Novoa · New York, US
Stefan McCarver · Princeton, US

Key dates

Filing date	Jun 3, 2016
Grant date	Oct 5, 2021
Priority date	—
Expiry date	Jan 25, 2037

Classification

Technology area (CPC B)Performing Operations; Transporting
CPC primaryB01J2540/225
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Synthetic methods are described herein operable to efficiently produce a wide variety of molecular species through conjugate additions via decarboxylative mechanisms. For example, methods of functionalization of peptide residues are described, including selective functionalization of peptide C-terminal residues. In one aspect, a method of peptide functionalization comprises providing a reaction mixture including a Michael acceptor and a peptide and coupling the Michael acceptor with the peptide via a mechanism including decarboxylation of a peptide reside.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.