Mutated immunoglobulin-binding polypeptides
US11136359B2 · kind B2 · utility
8Cited by
9References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 20, 2018 |
| Grant date | Oct 5, 2021 |
| Priority date | — |
| Expiry date | Feb 20, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K16/00
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The invention discloses a polypeptide with improved alkaline stability, which polypeptide comprises a mutant of a B or C domain of Staphylococcus Protein A (SpA), as specified by SEQ ID NO 1 or SEQ ID NO 2, or of Protein Z, as specified by SEQ ID NO 3, wherein at least the glutamine residue at position 9 has been mutated to an amino acid other than asparagine. The invention also discloses multimers of said polypeptide, as well as separation matrices comprising the multimers or polypeptides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.