Compositions and methods for diagnosing and/or treating kidney injury
US11136363B2 · kind B2 · utility
1Cited by
0References
11Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 1, 2019 |
| Grant date | Oct 5, 2021 |
| Priority date | — |
| Expiry date | Feb 1, 2039 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/347
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
One aspect of the technology relates to methods, assays and kits to identify ischemia and ischemic injury, including kidney injury, and are useful in determining efficacy of cancer treatments. In particular, differential phosphorylation of the nucleophosmin (NPM) polypeptide is an early marker of ischemic injuries such as kidney injury, AKI and ischemic renal cell injury. Another aspect of the technology relates to compositions and methods for the treatment of ischemia and kidney injury, including NPM inhibitory agents, including, but not limited to NPM inhibitory peptides for the treatment of ischemia and kidney injury.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.