IL-13 antibody and preparation method and use thereof

US11136387B2 · kind B2 · utility

Assignee

• SHANGHAI PHARMAEXPLORER CO., LTD. · CN

Inventors

• Yizhen YANG · Beijing, CN
• Shiyong GONG · Shanghai, CN
• Lijuan HAO · Shanghai, CN
• Jian WU · Zhengzhou, CN
• Xinxiu YANG · Shanghai, CN
• Qin ZHONG · Shanghai, CN
• Shaoping HU · Shanghai, CN
• Stewart Leung · Shanghai, CN
• Qing DUAN · Shanghai, CN
• Lile LIU · Shanghai, CN

Key dates

• Filing date: May 16, 2017
• Grant date: Oct 5, 2021
• Expiry date: May 16, 2037

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/5437
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention discloses IL-13 antibody, method of its preparation and use thereof. The IL-13 antibody comprises one or more of heavy chain CDR1, heavy chain CDR2 and heavy chain CDR3 of heavy chain variable region of the IL-13 antibody, and/or one or more of light chain CDR1, light chain CDR2, and light chain CDR3 of light chain variable region of the IL-13 antibody. The IL-13 antibody has a high affinity and can significantly inhibit the secretion of thymus activation-regulated chemokine and periostin as well as the expression of vascular cell adhesion molecule-1 induced by IL-13, it can significantly inhibit airway hyperresponsiveness in mice induced by IL-13, and therefore can be used in the preparation of drugs for preventing or treating IL-13 expression or dysfunction related diseases.