Composition for enteric hard capsule and method for producing enteric hard capsule
US11141381B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jul 5, 2017 |
| Grant date | Oct 12, 2021 |
| Priority date | — |
| Expiry date | Jul 5, 2037 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB29K2001/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A composition for an enteric hard capsule by taking advantage of conventionally unknown thermal gelation characteristics of a neutralized aqueous solution of an enteric polymer, so as to obtain an enteric capsule having sufficient water and acid resistances. More specifically, the composition has hypromellose acetate succinate having a molar substitution with an acetyl group per anhydroglucose unit of 0.6 to 0.8 and a ratio of the molar substitution with an acetyl group to a molar substitution with a succinyl group per anhydroglucose unit of 2.0 to 4.0, a neutralizer, and water method produces an enteric hard capsule having the steps of: immersing a core pin heated at 50 to 80° C. in the composition, taking the immersed core pin out of the composition, and drying a gel layer of the hypromellose acetate succinate formed on the taken-out core pin.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.