Pharmaceutical compounds

US11141406B2 · kind B2 · utility

Assignee

• REVIRAL LIMITED · GB

Inventor

• James Good · Stevenage, GB

Key dates

• Filing date: Dec 21, 2018
• Grant date: Oct 12, 2021
• Expiry date: Dec 21, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Benzimidazole derivatives of formula (I): (Formula (I)) wherein: R1 is —(CH2)m—R7, (Formula (II)) or (Formula (III)); R2 is H, halo, —(CH2)m—NH2, —(CH2)n—C(═NH)—NH2 or —(CH2)n—NH—(CH2)m—NHR9; R3 is H, F or Cl; each of R4, R5 and R6 is independently H or F; R7 is C1-C6 alkyl, CF3, —SO2R11, —NH—(CH2)2—(NH)r—R8, —NH—CH(R8R9) or a group of the following formula (A): (Formula (A)): W is —(CH2)m—, —CH2—O—CH2—, —CH2—S—CH2—, —(CH2)r—S(O)2—CH2— or —(CH2)r—NR8—CH2—; m is an integer of 1 to 3; n is 1 or 2; p is 1 and V is CH; or p is 0 and V is N; q is 0 or 1; r is 0 or 1; R8 is H, —SO2R11, —SO2CF3, —COR11, —C(O)OR11, —CON(R9)2 or —(CH2)nSO2R11; R9 is H or C1-C6 alkyl, each R9 being the same or different when two are present; R10 is —SO2R11, —SO2CF3, —COR11, —CON(R9)2 or —(CH2)nSO2R11; and R11 is C1-C6 alkyl; and the pharmaceutically acceptable salts thereof are inhibitors of RSV and can therefore be used to treat or prevent an RSV infection.