Buoyancy-activated cell sorting (BACS)-compatible activation/transduction systems and methods
US11141435B2 · kind B2 · utility
4Cited by
5References
24Claims
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Key dates
| Filing date | Mar 14, 2019 |
| Grant date | Oct 12, 2021 |
| Priority date | — |
| Expiry date | Mar 14, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2521/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are methods for contacting in a closed container a host liquid including target cells, microbubble reagents comprising gas-core lipid-shelled microbubbles, and one or more antibodies or other ligands that bind to cell surface molecules on the target cells, wherein the one or more antibodies or other ligands are bound to the target cells or the microbubbles, wherein the contacting under conditions to produce target cells linked to microbubbles via the one or more antibodies or other ligands and activating the target cells to generate activated target cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.