WNT signaling agonist molecules

US11142577B2 · kind B2 · utility

Assignees

• The Board of Trustees of the Leland Stanford Junior University · US
• University of Washington · US

Inventors

• Kenan Christopher Garcia · Menlo Park, US
• David Baker · Ann Arbor, US
• Claudia Yvonne Janda · South San Francisco, US
• Luke Dang · Carnation, US
• James Daniel Moody · Portadown, GB

Key dates

• Filing date: Sep 11, 2015
• Grant date: Oct 12, 2021
• Expiry date: Sep 9, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Wnt signaling agonist compositions and methods for their use are provided. Wnt signaling agonists of the invention comprise a frizzled binding moiety, which is fused or conjugated to an LRP5 or LRP6 binding moiety.