Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof
US11142780B2 · kind B2 · utility
3Cited by
1References
16Claims
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Key dates
| Filing date | Jun 27, 2017 |
| Grant date | Oct 12, 2021 |
| Priority date | — |
| Expiry date | Jun 27, 2037 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Y201/01128
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed herein are methods that may be used for the synthesis of benzylisoquinoline alkaloids (BIAs) such as alkaloid morphinan. The methods disclosed can be used to produce thebaine, oripavine, codeine, morphine, oxycodone, hydrocodone, oxymorphone, hydromorphone, naltrexone, naloxone, hydroxycodeinone, neopinone, and/or buprenorphine. Compositions and organisms useful for the synthesis of BIAs, including thebaine synthesis polypeptides, purine permeases, and polynucleotides encoding the same, are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.