Antibodies that specifically bind alpha klotho

US11143661B2 · kind B2 · utility

Assignees

• The Governing Council of the University of Toronto · CA
• The Board of Regents of the University of Texas System · US

Inventors

• Sachdev Sidhu · Toronto, CA
• Sarah L. Barker · Toronto, CA
• Orson W. Moe · Dallas, US
• Makoto Kuro-o · Sankt Gallen, CH
• Johanne Pastor · Flower Mound, US

Key dates

• Filing date: May 22, 2020
• Grant date: Oct 12, 2021
• Expiry date: May 22, 2040

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/56
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

An antibody and/or binding fragment thereof, wherein the antibody and/or binding fragment thereof comprises a light chain variable region and a heavy chain variable region, the light chain variable region comprising complementarity determining region (CDR) CDR-L3 and the heavy chain variable region comprising CDR-H1, CDR-H2 and CDR-H3, with the amino acid sequences of said CDRs comprising one or more of the sequences set forth below: CDR-L3; selected from any one of SEQ ID NOs: 123, 126-130, 142, 148 or 149; CDR-H1: SEQ ID NOs: 121 or 124; CDR-H2; SEQ ID NOs: 122 or 125; and/or CDR-H3: selected from any one of SEQ ID NOs: 196-226.