Methods of use for trisubstituted benzotriazole derivatives as dihydroorotate oxygenase inhibitors
US11147801B2 · kind B2 · utility
4Cited by
4References
12Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 19, 2018 |
| Grant date | Oct 19, 2021 |
| Priority date | — |
| Expiry date | Apr 19, 2038 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/02
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods for treating a cancer in a subject and for inhibiting tumor growth, metastasis or a dihydrorotate oxygenase enzyme activity of a tumor or cancer cell. At least one trisubstituted benzotriazole derivative with the formula (I) is administered to the subject or is contacted with the cancer cell. Compounds of formula (I) have substituents R1, R2 and R3 which have the meanings given in the specification, and pharmaceutically acceptable salts thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.