Tyrosine analogues derivatives as Rho-kinase inhibitors
US11147812B2 · kind B2 · utility
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14Claims
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Key dates
| Filing date | Sep 5, 2018 |
| Grant date | Oct 19, 2021 |
| Priority date | — |
| Expiry date | Oct 18, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to compounds of formula (I) inhibiting Rho Kinase that are tyrosine analogues derivatives, methods of preparing such compounds, pharmaceutical compositions containing them and therapeutic use thereof. Particularly the compounds of the invention may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.