Compositions and methods for treating diseases associated with uncontrolled inflammatory responses
US11147815B2 · kind B2 · utility
2Cited by
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36Claims
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Key dates
| Filing date | Aug 21, 2019 |
| Grant date | Oct 19, 2021 |
| Priority date | — |
| Expiry date | Aug 21, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods of treating, controlling or managing diseases associated with uncontrolled inflammatory responses are provided. These methods comprise the administration of small molecule compounds that alter the activity of Tripartite motif containing 8 (TRIM8) in blood monocytes. Also provided are pharmaceutical compositions that comprise small molecule compounds that specifically target the E2-RING domain or the RING-RING dimerization domain of TRIM8 for the treatment, control or management of diseases associated with uncontrolled inflammatory responses.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.