Engineered antibody constant regions for site-specific conjugation and methods and uses therefor
US11147852B2 · kind B2 · utility
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15References
27Claims
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Assignee
Inventors
Key dates
| Filing date | Dec 19, 2012 |
| Grant date | Oct 19, 2021 |
| Priority date | — |
| Expiry date | Apr 15, 2033 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/94
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is directed to antibodies, and antigen-binding portions thereof, engineered to introduce amino acids for site-specific conjugation. The invention relates to engineered antibody constant region (Fc, Cγ, Cκ, and Cλ) polypeptides, and portions thereof, and antibodies comprising the polypeptides. Further, the invention relates to Fc fusion proteins comprising an engineered Fc region. The invention also relates to methods and uses of the engineered antibodies and portions for, among other things, production of antibody-drug conjugate therapeutics.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.